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Decellularized matrix mediated cartilage regeneration and its significance for regenerative medicine



主   办:生物医学工程系
报告人:Dr. Ming Pei
时   间:上午9:00
地   点:廖凯原楼2-401会议室
主持人:葛子钢 研究员


报告内容摘要:

Cell-based therapy is a promising biological approach for the treatment of cartilage defects. Due to the small size of autologous cartilage samples available for cell transplantation in patients, chondrocytes need to be expanded to yield sufficient cell number for cartilage repair. However, either chondrocytes or adult stem cells tend to become replicatively senescent once they are expanded on conventional plastic flasks. Many studies demonstrate that the loss of cell properties is concomitant with the decreased cell proliferation capacity. This is a significant challenge for cartilage tissue engineering and regeneration. Despite much progress having been made in cell expansion, there are still concerns over expanded cell size and quality for cell transplantation application. Recently, in vivo investigations in stem cell niches have suggested the importance of developing an in vitro stem cell microenvironment for cell expansion and tissue-specific differentiation. Our and other investigators’ work indicates that a decellularized stem cell matrix (DSCM) may provide such an expansion system to yield large-quantity and high-quality cells for cartilage tissue engineering and regeneration. Further investigations of the underlying mechanism and in vivo regeneration capacity will allow this approach to be used in clinics in the near future. In this talk, tissue-specific stem cell will also be highlighted for a lineage-specific tissue regeneration, which guarantees an engineered cartilage tissue with high quality. This new strategy is also applied to other lineage tissue regeneration

报告人简介:

Dr.  Ming Pei

Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, USA

 

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